The National Drug Discovery Centre enables Australian medical researchers to access the latest in advanced ultra-high throughput screening, addressing a critical early challenge in the drug discovery pipeline.
We provide a fully staffed facility with an industry gold-standard robotic screening platform to miniaturise and automate your assay.
Our facilities are equipped with two ultra-high throughput robotic platforms for biochemical and cell-based assays. These configurable platforms can support incubation steps and multiple reagent additions, as well as readout options that include whole-plate fluorometric imaging, high-throughput flow cytometry, high-content imaging and multi-mode plate reader screens.
Your lab must have hands-on experience running the assay
Your reagents must be stable over the duration of the assay
Your assay must be demonstrated in 96-well format
Your assay must have a robustness > 0.4 and signal-to-background ratio > 2
You must be able to provide project-specific materials such as special cells or recombinant proteins
Your readout technology must be supported
Applicants from Australian research institutes and small-to-medium enterprises may be eligible to apply for an Australian Government-sponsored screening subsidy.
This subsidy reduces the costs of a standard screening campaign by 90 per cent. Subsidised screens will be awarded competitively through bi-annual selection rounds. Successful applications are chosen by an independent panel of drug discovery experts from around Australia.
The costs for these projects vary, but would typically be around $1.50 per compound to screen a library of 300,000 small molecules (before subsidy), provided that the assay can be miniaturised to 1536-well format.
Researchers who are ineligible to apply for subsidised screens are still encouraged to contact us regarding the possibility of collaborative or contract-based projects.
Applications for Round 3 of subsidised screens close 21 January 2021. Applications for COVID-19-related screens can be submitted at any time and will be reviewed on a rolling basis.